Different research activities are currently carried out at IMATI-CNR involving the exploitation of multi-level parallel systems in complex applications. An overview of issues arising from these activities will be presented referring to the following domains:
-	biomedical domain: aspects related with the use of multilevel parallel processing are considered with reference to molecular docking and tissues micro array analysis;
-	hydro-meteo domain: ongoing research activities to deploy on the Grid complex hydro-meteo workflows are shortly illustrated;
-	mechanical system design: the need of practical multilevel parallelism in the design and simulation of  mechanical  components are discussed. 
Current research activities and projects on these topics are described as well.