Today?s complex scientific problems are programmed on high-performance computing systems which are often developed as distributed systems. Monitoring and measurements can help in exploitation of distributed systems, especially in the context of performance. Collected measurements can be essential in terms of network behavior diagnosis and understanding how the Internet works and how to improve its operability. We have been designing a MWING scalable experimental framework to setup and carry out distributed monitoring and measurements. MWING is a good starting point in the design of HPC systems based on cloud computing paradigm. The system can synchronize the activity of measurement/monitoring autonomous software agents that collect information on various network performance/reliability characteristics, e.g. to measure the quality of communication services. MWING framework uses local and centralized databases. Locally gathered data can be uploaded in one place allowing further analysis of data, e.g. with the use of a professional data mining engine. MWING has been used in a global experiment to observe and predict network behavior in a real-life Internet-wide measurement distributed infrastructure.